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# Who owns Xenon Pharmaceuticals Inc. (ENDP)? Elite investor 13F holders

4 tracked elite investors reported holding Xenon Pharmaceuticals Inc as of 2026-06-30, including Caligan Partners, Tudor Investment, Renaissance Technologies LLC, D.E. Shaw. Who bought, trimmed or exited each quarter, with links to the original SEC 13F filings.

4 tracked investors currently reported holding · Latest report period: 2026-06-30 · Health Care · Pharmaceuticals, Biotechnology & Life Sciences

Xenon Pharmaceuticals Inc., a neuroscience-focused biopharmaceutical company, engages in the discovery, development, and delivery of therapeutics to treat patients with neurological and psychiatric disorders. Its product candidates include Azetukalner, a novel, potent Kv7 potassium channel opener which is in Phase 3 clinical development for the treatment of epilepsy, including focal onset…

## Reported holders and securities, including exits (up to 20)

| Investor | Security | Instrument | Report period | Filed | Value | Quantity | Units | Change | Source |
|  --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| [Caligan Partners](https://ownershiptrace.com/13f/investors/125) | Xenon Pharmaceuticals Inc | SHARE | 2026-06-30 | 2026-08-14 00:00:00 | 53717020.00 USD | 889944.000000 | Shares | reduce | [Original filing](https://www.sec.gov/Archives/edgar/data/1727492/0001420506-26-001809-index.html) |
| [Tudor Investment](https://ownershiptrace.com/13f/investors/94675) | Xenon Pharmaceuticals Inc | SHARE | 2026-06-30 | 2026-08-14 00:00:00 | 32919559.00 USD | 545387.000000 | Shares | add | [Original filing](https://www.sec.gov/Archives/edgar/data/923093/0000902664-26-003485-index.html) |
| [Renaissance Technologies LLC](https://ownershiptrace.com/13f/investors/63) | Xenon Pharmaceuticals Inc | SHARE | 2026-06-30 | 2026-08-13 00:00:00 | 11293960.00 USD | 187110.000000 | Shares | reduce | [Original filing](https://www.sec.gov/Archives/edgar/data/1037389/0001037389-26-000059-index.html) |
| [Duquesne Family Office](https://ownershiptrace.com/13f/investors/30) | Xenon Pharmaceuticals Inc | SHARE | 2026-06-30 | 2026-08-14 00:00:00 | 0.00 USD | 0.000000 | Shares | exited | [Original filing](https://www.sec.gov/Archives/edgar/data/1536411/0001536411-26-000006-index.html) |
| [D.E. Shaw](https://ownershiptrace.com/13f/investors/98) | Xenon Pharmaceuticals Inc | SHARE | 2026-06-30 | 2026-08-14 00:00:00 | 13515932.00 USD | 223922.000000 | Shares | add | [Original filing](https://www.sec.gov/Archives/edgar/data/1009207/0001104659-26-097217-index.html) |

Public disclosures can be delayed, incomplete, or amended. Report period describes a position date; transaction date describes a reported transaction; filed describes submission. A recent filing or page update does not establish a current holding. A dash means unavailable or not comparable, not zero.

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